Jean Despujols (Salles en Gironde 19 March 1886-Shreveport, 1965) was a French, later naturalised American, painter.
He was a pupil of Paul Quinsac at the école des Beaux-Arts of Bordeaux. In 1914 he won the Prix de Rome for painting but the outbreak of World War I suspended the French residencies at the villa Médicis. He had his stay in Rome after the charge with his fellow painter Jean Dupas. His interaction with America began in 1924-1936 as a researcher of the American art students sent to breakdown at the École des Beaux-Arts de Fontainebleau.
In 1936, he won the Prix de l'Indochine, and was chosen by the Grand Conseil Economique of French Indochina to take a tour of Vietnam, Cambodia and Laos painting and drawing what he saw.
When World War II broke out he emigrated to America, settling in Louisiana, and is buried at Greenwood Cemetery, Shreveport. The Texas oil millionaire Algur H. Meadows acquired a 360-piece accretion of oil paintings and watercolors in 1969 and the Meadows Museum of Art at Centenary College of Louisiana was built to home these paintings.